Malignant Osteopetrosis Community

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Brief Description

In osteopetrosis, osteoclasts do not function normally. Bone is deposited by osteoblasts, but not remodeled by osteoclasts. The results are dense hard bones that are actually more brittle because they lack the osteoclast-designed lattice work. Fractures can occur because the bones are brittle, and healing may be delayed because of impaired bone remodeling. In its most severe form, abnormal bone growth may impair the function of cranial nerves and the normal flow of spinal fluid.

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Synonyms

Marble bone disease, Albers-Schonberg disease, Albers Schonberg Disease, Generalized Congenital Osteosclerosis, Ivory Bones, Marble Bones disease, Osteosclerosis Fragilis Generalisata

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   sashaffer01

   

   humberside